17 Main Dish Casseroles That Never Disappoint

Casseroles are the ultimate solution for effortless, crowd-pleasing meals. Packed with flavor and easy to prepare, these one-dish wonders are perfect for feeding a group or enjoying leftovers the next day. From hearty classics to creative new takes, these 17 main dish casseroles are sure to satisfy every craving.

Cuban Sandwich Casserole

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Everything you love about a classic Cuban sandwich is layered into this hearty dish. Think tender pulled pork, tangy pickles, melted Swiss cheese, and golden bread, all baked until beautifully crisp and gooey!
Get the Recipe: Cuban Sandwich Casserole

Cauliflower Chicken Casserole

This is a wholesome, low-carb combination of tender chicken, roasted cauliflower, and a creamy cheese sauce that ties it all together. It’s perfect when you want something hearty but a little lighter.
Get the Recipe: Cauliflower Chicken Casserole

One Pot Cheesy Sausage and Rice Casserole

A close-up of a plate of cheesy sausage jambalaya, featuring sliced sausage, melted cheese, and rice, garnished with herbs. — One Pot Cheesy Sausage and Rice Casserole. Photo credit: Bagels and Lasagna.

This one-pot wonder combines smoky sausage, perfectly cooked rice, and loads of melty cheese for a comforting, no-mess dish. It’s the ultimate crowd-pleaser for busy weeknights.
Get the Recipe: One Pot Cheesy Sausage and Rice Casserole

Philly Cheesesteak Casserole

Packed with all the flavors of a traditional cheesesteak, this casserole is layered with seasoned ground beef, sautéed peppers and onions, and topped with ooey-gooey melted cheese.
Get the Recipe: Philly Cheesesteak Casserole

Cheesy Cabbage Beef Casserole

Cabbage beef casserole inside cast iron. — Cheesy Cabbage Beef Casserole. Photo credit: Low Carb – No Carb.

Tender roasted cabbage pairs beautifully with flavorful ground beef and rich layers of cheese in this dish. It’s a creative twist on meat-and-veggie casseroles that’ll keep you coming back for seconds.
Get the Recipe: Cheesy Cabbage Beef Casserole

Broccoli Chicken Cheese Casserole

A plate of chicken with rice garnished with parsley on a white surface with an orange napkin, wooden utensils, and ingredients nearby. — Broccoli Chicken Cheese Casserole. Photo credit: Bagels and Lasagna.

Juicy chicken, crisp-tender broccoli, and a cheesy sauce come together in this comforting dish. The golden breadcrumb topping adds just the right amount of crunch.
Get the Recipe: Broccoli Chicken Cheese Casserole

Broccoli Casserole

A casserole dish with broccoli and cheese in it. — Broccoli Casserole. Photo credit: Real Balanced.

Simple yet so satisfying, this broccoli casserole highlights fresh broccoli baked in a creamy, cheesy sauce. It’s a timeless favorite that everyone will love.
Get the Recipe: Broccoli Casserole

Casserole with Brussel Sprouts

If you love brussels sprouts, this creamy casserole will become a standout in your rotation. It’s loaded with cheesy goodness for a dish that’s indulgent yet veggie-packed.
Get the Recipe: Casserole with Brussel Sprouts

Cheesy Beef and Rice Casserole

Seasoned beef, perfectly cooked rice, and loads of gooey cheese make this casserole irresistible. It’s so comforting, you’ll want seconds (and maybe thirds)!
Get the Recipe: Cheesy Beef and Rice Casserole

Cajun Seafood Rice Casserole

Shrimp and rice in a skillet. — Cajun Seafood Rice Casserole. Photo credit: Call Me PMc.

This flavorful casserole takes your taste buds to the Gulf Coast. With seasoned rice, shrimp, and crab, it’s a zesty dinner that’ll delight any seafood lover.
Get the Recipe: Cajun Seafood Rice Casserole

Crockpot Chicken Enchilada Casserole

A set-it-and-forget-it crowd favorite! Shredded chicken, enchilada sauce, and layers of cheese come together to create this easy, slow-cooked delight.
Get the Recipe: Crockpot Chicken Enchilada Casserole

Cheesy Chicken Casserole

A fork is holding a piece of chicken and broccoli casserole. — Cheesy Chicken Casserole. Photo credit: Trina Krug.

This cheesy casserole is packed with tender chicken and a creamy, cheesy sauce. Every bite is rich and satisfying, making it a mealtime winner.
Get the Recipe: Cheesy Chicken Casserole

Cheeseburger Casserole

Imagine all the flavors of a juicy cheeseburger baked together in one pan. Every hearty bite is filled with comfort, from seasoned ground beef to gooey cheese and noodles.
Get the Recipe: Cheeseburger Casserole

Egg Casserole with Ground Beef

A person cutting a piece out of a casserole. — Egg Casserole with Ground Beef. Photo credit: Primal Edge Health.

This protein-packed casserole combines fluffy eggs with meaty ground beef for an easy meal. It’s a go-to option for breakfast, lunch, or dinner!
Get the Recipe: Egg Casserole with Ground Beef

Chicken and Stuffing Casserole Dish

A plate of stuffing with chicken on a table next to a skillet. — Chicken and Stuffing Casserole Dish. Photo credit: Little Bit Recipes.

Comfort food at its finest! This dish features tender chicken paired with stuffing and baked until soft and flavorful with golden, crunchy edges.
Get the Recipe: Chicken and Stuffing Casserole Dish

Cheesy Beef Casserole with Cauliflower Rice and Spinach

For those looking for a lower-carb option, this casserole delivers! It’s loaded with hearty beef, nourishing cauliflower rice, and nutrient-packed spinach, all wrapped in a cheesy, comforting hug.
Get the Recipe: Cheesy Beef Casserole with Cauliflower Rice and Spinach

Brussel Sprouts Casserole

This rich and creamy dish takes brussels sprouts to the next level. Baked with cheese and a bit of crunch, it’s a delightful way to enjoy this underrated veggie.
Get the Recipe: Brussel Sprouts Casserole