Preheat your oven to 350°F (175°C). Grease a loaf pan or line with parchment paper.
In a large bowl, combine ground beef, breadcrumbs, shredded cheese, crumbled bacon, egg, milk, ¼ cup ketchup, mustard, Worcestershire sauce, garlic powder, onion powder, salt, and pepper. Mix until well combined.
Shape the mixture into a loaf and place it in the prepared loaf pan.